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The major key with 2 sharps is D Major. This can be confirmed by looking at the key signature of D Major, which includes F# and C#. In music theory, when determining the number of sharps in a key, we can refer to the cycle of fifths, where each step to the right adds a sharp.

D Major is the second step in this cycle, resulting in a two-sharp key signature. Such keys enhance many musical compositions with their bright and adventurous sound. In contrast, the other options either have no sharps or more than two, thereby confirming D Major as the correct answer for the key with 2 sharps.